Tizanidine is a short-acting muscle relaxer that’s marketed under the brand name Zanaflex.
It is used to treat muscle spasms caused by certain conditions such as multiple sclerosis, ALS, or spinal cord injury.It is also prescribed off-label for certain headache disorders, symptoms of fibromyalgia, and as a sleep aid.
Tizanidine works by blocking nerve impulses that are sent to your brain. If you are suffering from spasms, cramping, and tightness of the muscles, your doctor may prescribe tizanidine.
Tizanidine does not cure these problems, but it may allow other treatment, such as physical therapy, to be more helpful in improving your condition. Tizanidine hydrochloride is a centrally acting ?2-adrenergic agonist. Tizanidine HCl (tizanidine) is a white to off-white, fine crystalline powder, which is odorless or with a faint characteristic odor used to help relax certain muscles in your body. It relieves spasms.

Tizanidine ‘High’ and Recreational Use

Because of tizanidine’s sedative effects, numerous online and anecdotal reports have suggested that some people abuse the drug for a narcotic-like “high.”
However, tizanidine is not a narcotic.
Take tizanidine only as directed by your doctor, and keep this and all other drugs away from children, teenagers, and anyone for whom the drug has not been prescribed.

Tizanidine Side Effects

Tizanidine has some common side effects that should go away with continued use, including:
Dry mouth
Tingling sensation in the arms, legs, hands, and feet
Stomach pain
Increased muscle spasms
Back pain
Light-colored stools
Tell your doctor if any of these symptoms are severe or do not go away.

Serious Side Effects of Tizanidine
Some side effects of tizanidine can be severe.
If you experience any of these symptoms, call your doctor immediately:
Extreme tiredness
Unusual bleeding or bruising
Lack of energy
Loss of appetite
Pain in the upper right part of the stomach
Yellowing of the skin or eyes (jaundice)
Unexplained flu-like symptoms
Seeing things or hearing voices that do not exist
Slow heartbeat
Changes in vision
Let your doctor know if you have any other unusual problems while taking tizanidine.
Tizanidine abuse?
Tizanidine acts directly on the central nervous system rather than the skeletal muscles.
Tizanidine seems to interrupt communication between certain areas of the brain and the spinal cord that results in sedation and altered the perception of pain.
Individuals abuse Tizanidine by taking more than the prescribed amount to enhance the sedating effects.

Tizanidine Dosage

Tizanidine is available in both capsule and tablet to form 2 mg and 4 mg tablets.
The medication in the capsule is absorbed differently by the body than the medication in the tablet, so one product cannot be substituted for the other.
When you have your prescription filled, look at the tablets or capsules in the bottle and make sure that you have received the right product.
Tizanidine also reacts differently depending on whether you take it with food or on an empty stomach, or if you sprinkle the contents of the capsule on food.
Tizanidine hydrochloride is supplied as 2mg and 4 mg tablets for oral administration. 
The usual starting dose is Tizanidine 2 mg taken by mouth every six to eight hours. A maximum of three doses can be taken in a 24-hour period. Your doctor could increase the strength in 2- to 4-mg steps to help reach the optimum effect and tolerance for your condition.
The initial dosage of tizanidine recommended for this patient with increased muscle tone associated with spasticity related to multiple sclerosis or spinal cord injury is tizanidine HCl 4mg orally once a day In order to reduce your risk of side effects, your doctor may direct you to start this medication at a low dose and gradually increase your dose.

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